More and more men are investing in longevity — and for good reason. With a record 74% of U.S. adult males now taking dietary supplements, there’s growing awareness of the factors that slow down or speed up aging. Whether it’s for energy, longevity, performance, or looks, men are seeking smart ways to increase their health span and lifespan.
With so many supplement options out there, however, it helps to know which ingredients are science-based and which ones are just trends. In this guide, we’ll break down the most effective, research-backed anti-aging supplements for men, including NOVOS Core, to help you make informed choices for your health.
Why Men Need Specific Anti-Aging Support
Aging affects everyone, but certain biological and lifestyle factors affect men differently than women.
Hormonal Changes
Testosterone levels naturally drop about 1% per year after age 30. While gradual, this decline can impact energy, strength, mood, and sleep over time. Higher body mass index (BMI) tends to make matters worse. Excess weight adds stress to the body and appears to reduce both testosterone production and how well it’s distributed.
Learn why we don’t recommend testosterone replacement therapy for anti-aging here.
Muscle Mass Declines
Men typically have more lean muscle than women, but aging diminishes that advantage. Starting around age 30, men can lose up to 3% to 5% of muscle mass per decade, slowing metabolism and increasing the risk of insulin resistance and frailty. Without support, this muscle loss, known as sarcopenia, can make it harder to stay active and maintain a healthy weight.
Cardiovascular & Cognitive Health Risks
Men generally face a higher risk of heart disease in midlife. When it comes to cognition, research shows more nuanced differences between men and women. A study published in the Journal of Alzheimer’s Disease found that men over 50 who develop mild behavioral impairment — which may present as apathy, social withdrawal, mood changes, and other symptoms — may experience faster cognitive decline than their female peers.
The Science Behind Anti-Aging Supplements
At the cellular level, several overlapping processes drive aging. Oxidative stress accumulates, damaging cells much like rust eats away at metal. Inflammation may become chronic, and mitochondria — the energy producers in your cells — start to decline in function. Meanwhile, some cells stop dividing and become senescent “zombie” cells that linger and release harmful compounds, accelerating tissue breakdown.
Each of these processes contributes to aging, and they don’t happen in isolation. That’s why most so-called anti-aging supplements miss the mark. As we explain in this article, many are built on outdated assumptions, like the idea that antioxidants alone can slow aging. Others rely on ingredients with little to no scientific backing or use doses too low to be effective. Some formulas only focus on one or two pathways, when aging is a complex process with multiple causes.
Another important factor to consider is product quality and safety. In one study analyzing 30 immune-supporting supplements sold on Amazon, researchers found that more than half had issues: 17 had inaccurate labels, 13 were misbranded, and nine contained unlisted ingredients. That’s why it’s best to purchase supplements directly from the manufacturer when possible, where quality control and transparency are more reliable.
With NOVOS Core you’re getting a formulation that’s U.S.-manufactured, third-party tested, and backed by a team of longevity scientists. It includes 12 ingredients that work together to support mitochondrial health, reduce inflammation, repair cellular damage, and help clear senescent cells. It’s a more comprehensive way to support healthy aging at the root level.
Top Ingredients in Men’s Anti-Aging Supplements
So, which compounds actually work? Let’s explore our top picks when it comes to anti-aging supplements for men.
Glycine
- Supports restful sleep and calm brain activity
- May reduce oxidative stress in older people
- Enhances mitochondrial health
- Boosts glutathione, a master antioxidant
Alpha-Ketoglutarate (AKG)
Magnesium
- Critical for testosterone production, as one study showed that men who supplemented with magnesium over a four-week period had an increase in testosterone levels
- Acts as a cofactor to hundreds of different enzymes, which require magnesium to function properly
- Improves relaxation and sleep
Vitamin C
Glucosamine Sulfate
- Supports heart health
- Helps support healthy joints and cartilage
- Enhances skin health by promoting collagen production
Fisetin & NMN
- Fisetin: A plant-based polyphenol with senolytic properties that may help eliminate senescent cells
- NMN: Boosts levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme that declines with age
With the exception of NMN, the key ingredient in NOVOS Boost, all of the ingredients above are included in NOVOS Core. Just one sachet a day is all you need to support longevity, making it one of the most convenient anti-aging supplements for men.
What To Look for in a Men’s Anti-Aging Supplement
Here’s what separates NOVOS Core from the rest:
- Clinically studied ingredients based on science, not trends
- Backed by leading researchers in aging and cellular health
- Third-party tested for purity and potency
- U.S. manufacturing with sourcing from trusted global partners
- Ingredients designed to work together for synergistic benefits
If you want an anti-aging supplement for men that checks every box, try NOVOS Core. It targets multiple aging pathways, from inflammation to mitochondrial decline, supporting male aging and enhancing both health span and lifespan.
Future-Proof Your Health
Aging is inevitable. But how you age is largely up to you.
Science now offers powerful tools to help you stay sharper, stronger, and more resilient in your older years. The best anti-aging supplements for men don’t just target symptoms or isolate a single aging marker; they support longevity from the inside out.
Start your journey today with NOVOS Core, the trusted, science-backed supplement for men who want to live younger for longer.
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